Custom-made Ready Prepared Culture Media * ISO 9001:2008 * ISO 11133 * Harmonized USP/EP/JP * FDA 21 CFR part 11 compliant
Latest news: Colorex™ KPC - K603P090KP
For Detection of gram-negative bacteria with a reduced susceptibility to most of the carbapenem agents.
Typical Appearance of microrganisms
E.coli CarbapenemR → Dark pink to reddish
Klebsiella, Enterobacter, Citrobacter CarbapenemR → Metallic blue
Pseudomonas CarbapenemR → Cream, translucent
Other bacteria → Usually inhibited
Focus on KPC Resistance
KPC carbapenemase is an enzyme class, first found in Klebsiella pneumoniae isolates (hence, the name).
However, it can be produced by other organisms including Serratia spp., Enterobacter spp., E. coli, Citrobacter freundii and Salmonella enterica.
KPC resistance Epidemiologic Issues
Carbapenems are the last resort in treating many serious gram-negative infections. However, production of these enzymes results in resistance to penicillins, cephalosporins (i.e., cefepime, ceftriaxone), carbapenems (i.e., meropenem, ertapenem), and aztreonam, thereby making these pathogens truly multidrug-resistant and making their treatment very challenging.
« KPC-producing bacteria have demonstrated a remarkable ability to disseminate with interfacility, interstate, and international transmission having been documented. » CDC 2008-R-24.
Thus, in order to limit the spread of these serious pathogens, rapid detection, followed by implementation of adequate infection control methods, is essential.
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